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• Short-term: Problems with attention, learning, and memory; dreamlike states, hallucinations; sedation; confusion; loss of memory; raised blood pressure; unconsciousness; dangerously slowed breathing.
• Long-term: Ulcers and pain in the bladder; kidney problems; stomach pain; depression; poor memory.

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The most common side effects associated with ketamine when used medically are nausea, vomiting, dizziness, diplopia (double vision), drowsiness, dysphoria (unease, restlessness), and confusion. There is also the risk of HIV, hepatitis, and other infectious diseases from shared needles.

Ketamine use can be fatal in people who are alcoholics or acutely intoxicated with alcohol.

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• With an overdose of ketamine, emergency care, such as 911, should be contacted immediately.
• There is no antidote for this drug. In the emergency department, adverse effects typically resolve in 1 to 3 hours.
• Benzodiazepines such as lorazepam may be used if needed for seizures, excitation, or muscle rigidity.
• Respiratory depression may be more likely if combined with sedatives.

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